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Description

J Neurophysiol 2006

In addition, CB-839 has been extensively studied in hematological malignancies such as acute myeloid leukemia (AML) (Okabe et al., 2022), and multiple myeloma (MM) ( TABLE 2 Clinical trials on targeting glutamine metabolism

It is worth noting that when glutamine is depleted, upregulated amino acid transporters, such as SLC1A3 (aspartic acid/glutamate transporter) and SLC7A3 (arginine transporter) were observed