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Another model for cerebral ischemia is cell ablation via bacterial nitroreductase catalysis of toxic metronidazole, under the control of a neuroendothelial cell-specific promoter, which can damage brain tissues

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GST-pi is a phase II enzyme that catalyzes the reaction of the GSH thiolate to toxic electrophilic compounds, thus allowing highly reactive carcinogens or radicals to be eliminated by excretion machinery 54, 55