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Given its potent redox capabilities, and its high intracellular concentration and widespread distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well-established

2 Pathophysiological foundations of chemotherapy-induced neurotoxicity The development of CIPN involves multiple convergent mechanisms that fundamentally alter the neurobiological landscape of peripheral nervous system function

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Compared to the subjects without RA, the subjects with RA resulted in an increased incidence of ESRD (incidence rates of 0.374 versus 0.810 cases per 1,000 person-years)