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PLoS ONE 6(7):e21643 Hanger DP, Anderton BH, Noble W (2009) Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Slowing down visible signs of aging

This could answer the reason why curcumin generates ROS by irreversibly modifying the anti-oxidant enzyme thioredoxin reductase, inducing topoisomerase II-mediated DNA damage and inactivating the tumor suppressor protein