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For the researchers, parenteral high-dose thiamine was effective in reversing Parkinsons disease symptoms, that a dysfunction of thiamine-dependent metabolic processes could cause selective neural damage in the centers typically affected by this disease and that Thiamine could have both restorative and [nerve-protecting] action in Parkinsons disease. Source: Costantini, Antonio, Maria Immacolata Pala, Enzo Grossi, Stella Mondonico, Luisa Ercoli Cardelli, Carina Jenner, Sabrina Proietti, Marco Colangeli, and Roberto Fancellu

SIRT2 delactylates USP2 K447 and inhibits the activity of USP2 The above data confirmed that TGF1 promoted the lactylation of USP2 K447 while SIRT2 OE decreased it

This means food remains in the stomach longer than normal, which can trigger feelings of fullness, bloating, and nausea, especially after eating larger meals or difficult-to-digest foods

Elevated Hcy levels result in heightened excitatory glutamatergic neurotransmission in various brain regions, contributing to neuronal damage