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Current evidence suggests that high-dose B12 supplementation can trigger acne in susceptible people by altering skin bacteria behaviour, though this does not affect everyone

visceral fat fell about 40%. After withdrawal, insulin resistance returned in proportion to regained weight. Maintaining some weight loss did not preserve the full metabolic benefit when substantial regain occurred

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Recent studies have suggested that Vit B12 deficiency along with the induced hyperhomocysteinemia are correlated with specific PD phenotypes characterized with early postural instability and falls and more rapid motor progression, cognitive impairment, visual hallucinations and autonomic dysfunction