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Knocking it out had minimal impact on the histology of liver fibrosis under CCl 4 stimulation but significantly exacerbated intrahepatic inflammatory infiltration in lobular areas, accelerated ECM remodeling characterized by an upregulation of insoluble matrisome members within the ECM, and activated focal adhesion (FAK) signal in HSCs, hindering liver fibrosis regression after CCl 4 cessation