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Given that the blood-brain barrier (BBB) excludes many systemic therapies, local control approaches such as surgical resection are used for initial management, often in combination with radiotherapy [4]

Taken together, these findings suggest that serotonergic hypoactivity alone does not fully account for the complex pathophysiology of MDD

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In addition, most of the effective analgesics in NP failed to provide symptomatic relief of CIPN and often exhibit side effects (Han and Smith, In general, unlike other types of NP (including those induced by trauma and diabetes) axonal degeneration in peripheral nerves is not present in CIPN (Ji et al., Regarding to CIPN induced by the taxanes, Duggett et al