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the bioavailable to the lens dose amount of lipoic acid or a derivative thereof is about 5 M to about 250 M or about 10 M to about 700 M

Nucleotide excision repair (NER) eliminates a series of helix-distorting lesions that are mostly induced by UV irradiation, 76,77 whereas base excision repair (BER) primarily acts on the modification of oxidative bases, 78,79 and mismatch repair (MMR) scans for incorrectly inserted nucleotides during replication

Graphical Abstract Similar content being viewed by others Introduction RNA therapies have emerged as superior alternatives for the rapid and efficient treatment of acute and life-threatening diseases compared with other approaches

79 Therefore, additional studies are needed in order to refine the diagnosis of discogenic LBP and to identify candidates who would concretely benefit from IVD regeneration with stem cells