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Weight loss has been associated with improvements in liver enzymes and histology in a number of different patient populations, and the associated metabolic improvements are likely to be mediated via reduction in adipose tissue inflammation and secretion of pro-inflammatory adipokines (278281)

And therefore we are cautious and advise against any topical use of retinoids during pregnancy

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Clausse, V., Goloudina, A., Uyanik, B., Kochetkova, E., Richaud, S., Fedorova, O., Hammann, A., Bardou, M., Barlev, N., Garrido, C., and Demidov, O., Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy, Cell Death Dis , 2016