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Venkatesan D, Iyer M, Narayanasamy A, Siva K, Vellingiri B

These engineered drug delivery systems significantly enhance therapeutic outcomes in gout and hyperuricemia by improving drug solubility, enabling targeted delivery, providing sustained release, facilitating synergistic drug co-delivery, and responding to pathological microenvironments, although preclinical evidence is limited and clinical evidence supporting their efficacy and safety remains sparse

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Wexler T, Gunnell L, Omer Z, Kuhlthau K, Beauregard C, et al

Alternatively, pentose phosphate for nucleotide synthesis can be generated from glycolytic intermediates by the reversible reactions of the non-oxidative phase