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Further information is available from the corresponding author upon reasonable request

J.DeYoungC

It is important to consider caveats in studies on mitochondrial bioenergetics, electron, and proton leak including the penetrance of mitochondrial inhibitors and the challenge of uniformly delivering drugs to all cells within islets

Pediatric protocol (ages 3-12): Dose: 16 IU twice daily (32 IU total daily) Administration: Morning and evening Duration: 12 weeks in clinical trials Adult protocol: Dose: 24 IU twice daily (48 IU total daily) Administration: Morning and evening Duration: Variable, typically 4-12 weeks A 2025 meta-analysis found that high daily doses (48 IU) showed beneficial effects on social impairments, while lower doses showed no significant difference from placebo