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10% of seed culture were inoculated in PSB and cultivated at 25 for 4 days with shaking in dark, then cultivated with light for 6 days

Impairment in Glutathione peroxidase 4 (GPX4) function, which attenuates cellular redox defense, i s also associated with cartilage extracellular matrix (ECM) damage (Miao et al., 2022) implying targeting ferroptosis as a promising new direction for possible interventions in OA pathogenesis

Can also experience muscle cramps, muscle weakness, spastic muscles, and Charlie horses

Emerging technologies, including artificial intelligence, multi-omics approaches, novel modeling systems such as skin organoids, and precision medicine, are being explored to address these challenges