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They signal through a shared, ubiquitously expressed heterodimeric receptor (IFNAR), and prime a rapid antiviral response that acts directly or indirectly on many cell types, including NK cells, T cells, B cells, DCs, and macrophages ( + T cells in response to viral infections, which is thought to permit a more vigorous, diverse, and efficient T cell response emanating from the nave T cell pool ( + T cells (CTLs) ( in vivo and sustaining antiviral immunity

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Despite the presence of FIH-1, angiogenesis, metastasis, migration, and other phenomena necessary for cellular proliferation take place