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217 SirakawinC.LinD.ZhouZ.WangX.KelleherR.HuangS.et al (2024)

There is no risk of serotonin syndrome with SAMe in dogs as there is with combining certain human antidepressants, since SAMes mechanism is not directly as a serotonergic drug but as a metabolic enhancer

Certain situations require extra caution

Deletion of nuclear factor ImerC (NFI-C) leads to overexpression of plasminogen activator I (PAI-1) and subsequent inhibition of uPA activity and HGF signal, thus impairing hepatocyte proliferation (Marubashi et al., 2004)