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Studies have shown that TMAO is an independent risk factor for the occurrence of malignant adverse cardiovascular events, but whether it is harmful or beneficial to patients with cardiovascular diseases with mild or no clinical manifestations remains controversial

10.1016/j.celrep.2017.07.055 110 XueM.TianY.SuiY.ZhaoH.GaoH.LiangH.et al (2022)

Studies have reported that approximately 98% of the administered EC remains within the gut shortly after ingestion ( In a radiolabeled study using (2- 14 C)-EC in rats, less than 0.1% of the administered dose was detected in the brain, testes, spleen, heart, skeletal muscle, and lungs

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