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For instance, experimental studies that involve glutathione (Yamasoba et al., Figure 2 Consistent with this idea, glutathione, a tripeptide molecule (cysteine, glutamic acid, and glycine) and the most abundant endogenous free radical scavenger in humans, was the first antioxidant evaluated for the treatment of NIHL (Yamasoba et al., N-acetylcysteine (NAC), a cysteine precursor, is an antioxidant molecule that enhances the production of glutathione (Kopke et al., a replenisher of this endogenous scavenger (Kopke et al., Interestingly, recent evidence suggests that HK-2, a multifunctional antioxidant with a metal chelator and free radical scavenger properties (Kawada and Kador, Several micronutrients such as vitamins A, C, and E show antioxidant properties and have been used either individually or combined as experimental treatments for NIHL

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Hepatic injury related to antithyroid therapy such as methimazole is well documented in humans and reported in the cat.22, 32 Mild histologic changes are common, but cases of fulminant hepatic failure with central lobular necrosis have been described