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Liver and Brain Dysfunction When oxygen levels drop below 2%, the liver reduces hemoglobin production, leading to hypoxia, impaired energy production, and increased red blood cell (RBC) destruction.76 Chronic liver damage is linked to processing RBC byproducts like hemoglobin, iron, and cholesterol, which accumulate in organs like the liver, pancreas, and bone marrow, disrupting metabolism

Cudmore J, Seftel M, Sisler J, Zarychanski R (2014) Methotrexate and trimethoprim-sulfamethoxazole: toxicity from this combination continues to occur

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