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As discussed above, excessive ROS influences the hypothalamic-pituitary adrenal axis (HPA) and in turn releases corticosterone and cortisol in animals and humans, which induces stress

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It acts centrally to reduce appetite , slow gastric emptying , and suppress glucagon release

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This was expected, as weight loss achieved with any intervention in people without T2D generally exceeds that seen in people with T2D [42]

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