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In addition, cyanocobalamin can be used externally for neurodermatitis and psoriasis

CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy

These include: Tingling, numbness, or a 'pins and needles' sensation in the hands and feet Difficulty with balance and coordination Muscle weakness Memory problems, difficulty concentrating, or 'brain fog' Mood changes, including low mood or irritability Important: New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change should be treated as urgent

The Phase 2 clinical trial showed approximately 2-3 kg of additional fat loss compared to placebo over 12 weeks