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In a separate set of experiments performed in the other participating laboratory in Turin with the Palo Alto parasite strain, similar data were obtained, showing that the invasion rate of GR-deficient RBCs was as high as that of control RBCs (30% parasitemia at 19 h after inoculation with 6.4% schizonts), and regular development into trophozoites was observed on day 2 (30% parasitemia)

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Mechanistically, 4-HBGs neuroprotective efficacy against glutamate excitotoxicity has been attributed to competitive inhibition of kainate receptor binding (Andersson et al., 1995), corroborating its therapeutic potential despite moderate systemic exposure

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