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To mitigate these concerns, we prioritized age-appropriate pediatric controls, used the adult dataset only for cell-type annotation, and performed sensitivity analyses using Asia-based external cohorts, which supported the directionality of key CD4 T cellrelated findings

In CRC, combining 5FU with DNA-damaging agents oxaliplatin and/or irinotecan was an empirical choice rather than a rationally designed strategy, and no new combination partners have been added since the introduction of the biological EGFR and VEGF-targeting agents in the early 2000s

doi: 10.1007/s42000-018-0063-z

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