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Introduction Melatonin (MT), secreted by the midbrain pineal gland and some peripheral tissues, is a tryptophan metabolite that activates multiple intracellular signaling pathways ( Parkinsons disease (PD) is a neurodegenerative disease with motor and non-motor symptoms characterized by the loss of dopaminergic neurons in the nigrostriatal and the formation of Lewy body proteins ( -syn aggregation, and alterations in neurotransmitters ( There is emerging evidence supporting the impact of oxidative stress on PD, and therefore, drugs with antioxidant activity are expected to be a potential treatment for PD ( -syn aggregation, and dopamine loss in PD ( The nematode Caenorhabditis elegans ( C

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