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Conversely, both apoB100 and MTTP are negatively regulated by insulin, which reduces hepatic lipid export by inducing apoB100 degradation and suppressing MTTP synthesis [111]

The mRNA expression of HDAC2 both in peripheral blood and in sputum showed a decreasing trend (due to the lower sample size, there was no statistical significance)

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These results suggested that by preventing Sab phosphorylation, fomepizole interrupted the amplified oxidative stress cycle, stopped ROS production and halted activation of ASK1/2 ( Figure 23 )