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All mammalian tissues express MAT and MS, whereas BHMT is limited to the liver and kidney (Lu and Mato, 2008)

However, since GST is a large tag, the potential for degradation by proteases is higher than for smaller tags

The risks of arthritis, advanced liver fibrosis, cirrhosis and the subsequent development of primary liver cancer increase with progressive iron loading, particularly when the serum ferritin level exceeds 1000 mcg/L