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NNMT Inhibition, NAD+ & Obesity/Type 2 Diabetes Pathway Review (PMC, 2021) 5-Amino-1MQ as a Validated Research Tool for NNMT-Linked Metabolic Pathways A comprehensive review of NNMTs roles in obesity and type 2 diabetes published in BioMed Research International and indexed on PubMed Central evaluated 5-Amino-1MQ alongside other NNMT inhibitors

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Discussion Here we demonstrate here that selectively targeting the CD38 NADase ectoenzyme with the catalytically inhibitory heavy-chain monoclonal antibody can mitigate skin and lung fibrosis in mice