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This Review presents an updated clinical approach to the diagnosis and management of SLOCA that focuses on the most important developments in this field

Excessive production of RAGE on brain microvascular endothelial cells increases A transport into the brain tissue and decreases its removal, leading to the accumulation of A in the brain tissue, which in turn triggers a series of neurodegenerative pathological changes, such as the formation of amyloid plaques, the formation of neurofibrillary tangles, and the loss of neurons (23)

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For example, berberine and palmatine have been reported can exert various pharmacological activities, such as anti-inflammatory, chondroprotective, and neuroprotective properties (Singh et al., 2019