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Description

The present study sought to investigate the changes in mitochondrial physiology in FRDA-like cerebellar granule neurons and glia, by using hemizygous YG8R mice (with a defective FXN transgene) and hemizygous Y47R mice (with a normal FXN transgene)

J Exp Med 177 : 15471552 Cossarizza A, Franceschi C, Monti D, Salvioli S, Bellesia E, Rivabene R, Biondo L, Rainaldi G, Tinari A, Malorni W (1995) Protective effect of N -acetylcysteine in tumor necrosis factor- -induced apoptosis in U937 cells: the role of mitochondria

The mitochondria presented themselves as continuous filaments in the hippocampal neurons of the NC group whilst they showed more obvious fragmentation after treatment with ROT (Fig