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Chronic IH may also result in an imbalance in the ratio of arginase-1 (an enzyme that competes with eNOS for L-arginine) to eNOS expression, resulting in decreased NO availability, a key feature of ECD [149]

We further demonstrate that the previously recognized ferroptosis suppressor FSP1 is the vitamin K reductase that sustains a warfarin-insensitive non-canonical vitamin K cycle that suppresses ferroptosis by maintaining VKH 2 at the expense of NAD(P)H to prevent lipid peroxidation (Fig