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By selectively inhibiting NNMT activity, researchers study how changes in nicotinamide metabolism influence intracellular NAD availability, methylation balance, mitochondrial efficiency, and lipid metabolism

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A randomized, double-blind, placebo-controlled study of oral vitamin B12 supplementation in older patients with subnormal or borderline serum vitamin B12 concentrations

doi: 10.3389/fimmu.2026.1769281 Received 16 December 2025 Revised 08 April 2026 Accepted 13 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Douglas Sborov, The University of Utah, United States Reviewed by Nomie Leblay, University of Calgary, Canada Xuan Jiang, Shanghai Jiao Tong University, China Updates Copyright 2026 Horenstein, Frerichs, Faini, van de Donk and Malavasi