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Chronic infections, including those caused by Helicobacter pylori and Mycobacterium tuberculosis , exploit mitochondrial manipulation to facilitate long-term persistence within the host, thereby evading immune clearance ( Therapeutic strategies designed to counteract pathogen-induced mitochondrial dysfunction focus on restoring mitochondrial integrity and immune balance

This decreases phosphorylation of transcription factors, such as TFEB, TFE3 and others 103 , by this kinase, enabling their nuclear translocation to drive expression of genes encoding many components of lysosomes and additional autophagosome machinery 13,103105