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Several studies have found that chronic ethanol treatment causes decreased methylation of the DAT1 promoter, resulting in the upregulation of DAT in a variety of brain regions (5456)

Reference: Krivic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P

Targeting FIT2, a protein essential for LD formation, the authors demonstrated reducing LD accumulation in brain macrophages could restore their pathological phenotypes in an AD mouse model (Wu et al., 2025)