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The genetically modified mouse models and wild-type C57BL/6 mice were produced and maintained in standard conditions of light (12 h light/ dark cycle) and temperature (22 1 C)

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The results suggested that the additional amino acids had little effect on the enzyme activity

Understanding the biomechanics of sports-related concussions in youth requires knowledge about what head and neck movements and applied forces occur in an array of sporting environments, how the developing head and neck mechanical and biological properties change with age and gender, how mechanical responses change during development, and how tissue deformations or changes in physiology (e.g., CBF, metabolism) produced by these motions and forces may directly or indirectly cause a concussion