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Internally, sperm mitochondria are a major source of ROS

T-GLC-EXA ADC and T-VA- EXA ADCs were formulated, using model human HER2 targeting trastuzumab monoclonal antibody as targeting moiety

Combining carboplatin with the ROS-inducing compound sulfasalazine reduces the carboplatin IC 50 in TNBC [54], further supporting the therapeutic strategy of glutathione depletion to enhance chemotherapy efficacy [19]

This includes the possibility that specific genes or subsets of genes can control specific phenotypes of DS, but also that a nonspecific dose of a number of trisomic genes leads to a genetic imbalance that has a major impact on the expression and regulation of many other genes throughout the genome