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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

Low creatinine was defined as less than 0.4 (younger) or 0.5 (older) mg/dl

The authors are grateful for the technical support provided by SGIker (UPV/EHU)

If you are considering them, the conversation should include: Clear goals Baseline biomarkers Regulatory awareness Risk discussion Defined review timeframes Optimisation without measurement is guesswork