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Oxid Med Cell Longev 2022:4776243

A Phase 2 trial (Obesity Research, 2004) found 12 weeks of subcutaneous AOD-9604 produced statistically significant abdominal fat reduction versus placebo without altering fasting glucose or insulin levels

Moreover, in obese adipose tissue, ZIP14 downregulation has been associated with the increased expression of several cytokines, such as TNF-a and IL-10 (256)