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The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability resulting in approximately three times greater potency than IGF-1, with a significantly longer half-life of about 2030 hours relative to IGF-1s half-life of about 1215 hours

Low levels of B12 can cause fatigue, nervousness, dizziness, numbness, and tingling in the fingers and toes

When combined with hyaluronic acid, it appeared to enhance cartilage formation more effectively than either treatment alone

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