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a peak incidence of spina bifida was noted amongst men conceived between February and March 1945, i.e., the depths of the Dutch famine during World War II ( Because folate status is a major determinant of blood homocysteine concentrations, the possible contribution of elevated homocysteine to the pathogenesis of NTDs has been postulated

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Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders