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In vivo, PS-NPs co-exposure exacerbated renal CaOx deposition, ferroptosis in renal tubular epithelial cells, and inflammatory responses in the rat model

J Clin Invest (2019) 129(6):2293304

Stimulated by TNF- and IL-1, RANKL secreted by synovial fibroblasts induces macrophages to transform into osteoclasts ( Another major reason for fibroblast-induced disease in synovial tissue is that these cells are resistant to apoptosis ( Synovial hyperplasia induced by metabolic conversion may originate from signaling

Identification of the shift may help an individual identify which natural compounds activate their autoimmunity and which natural compounds help potentially dampen their autoimmunity