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In 2016, John Ioannidis of Stanford warned that there is massive production of unnecessary, misleading, and conflicted systematic reviews and meta-analyses. Quoting a 1990 paper, Allison said: As Ingram Olkin stated years ago, Doing a meta-analysis is easyDoing one well is hard. Like Retraction Watch

Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion

ii) Biomarker development: A lack of specific and reliable biomarkers limits the ability to monitor ferroptosis in clinical settings

Peer review Peer review information Nature Immunology thanks Felipe Andrade, Andras Perl, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work