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The mechanisms of natural products in regulating Nrf2-associated cellular processes were summarized and tabulated in Table 2

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

The enzyme glutathione reductase (GR) recycles GSSG to GSH while simultaneously oxidizing ?-nicotinamide adenine dinucleotide phosphate (?-NADPH2)

Mitochondria-Associated Membranes: Sites of ERMitochondrial Membrane Interaction The ER is a complex cellular organelle, formed by an interconnected network of cisternae (146), is distributed across the cell and is involved in numerous processes, including lipid and protein synthesis