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(2018) 49:560575.e6

Preclinical PTSD models consistently implicate gut barrier dysfunction, immuneinflammatory activation, HPA axis dysregulation and neurotransmitter imbalance as key mechanistic through-lines (Sherin and Nemeroff, 2011

Conflict of interest: All authors: Nothing to disclose P638 Clinical usefulness of pre-transplant and early post-transplant MRD quantification in patients with FLT3+ AML Gillen Oarbeascoa 1 , Carolina Martinez-Laperche 1,2 , Ana Prez-Corral 1,2 , Cristina Pascual 1,2 , Nieves Dorado 1,2 , Laura Solan 1,2 , David Serrano 1,2 , Pascual Balsalobre 1,2 , Javier Anguita 1,2 , Jose Luis Dez-Martn 1,2 , Ismael Buo 1,2,3 , Mi Kwon 1,2 1 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2,3 1,2 1 Hospital General Universitario Gregorio Maraon, Hematology Department, Madrid, Spain

IGF-1 LR3 is part of a family of growth factors that includes IGF-1, IGF-2, and insulin, all of which interact with various receptors and binding proteins to regulate cell proliferation, differentiation, and growth