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This interaction will initiate the signaling cascade and activation of transcriptional factors such as nuclear factor of activated T cells (NFAT), activator protein 1 (AP-1), and nuclear factor of kappa light chain enhancer in B cells (42)

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In the case of nerve root impingement from spinal lesions, such as herniated disks, osteophytes, or later- al recess stenosis, the referred pain pattern follows a well known dermatomal distribution and is often recognized as such

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