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AS-IV targets the overexpression of miR-362-3p and negatively regulates the activity of its downstream transcription factor RUNX1 in rat lung tissue and alveolar epithelial cells to alleviate the inhibitory effect of PM2.5 on the proliferation of rat alveolar epithelial cells L2 and its driving effect on LDH release

First, the period covered by the studies is more than thirty years, a period which has seen a considerable change in the diagnostic criteria, a variation in the test measures used, and a significant development of the methodology for AD and MCI investigation

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doi: 10.3389/fncel.2025.1669272 Received 19 July 2025 Revised 10 December 2025 Accepted 12 December 2025 Published 17 February 2026 Volume 19 - 2025 Edited by Luca Raiteri, University of Genoa, Italy Reviewed by Cataldo Arcuri, University of Perugia, Italy Updates Copyright 2026 Uemura, Hiro, Attachaipanich, Du, Yusof, Kinoshita, Hikosaka and Ohtsuki