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Fukutomi T, Takagi K, Mizushima T et al (2014) Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and keap1

Only 7%8% of individuals with AUD received any treatment in 2019, while less than 2% were prescribed an FDA-approved medication for the treatment of AUD

Considering that the TNF--induced H 2 O 2 burst has been previously shown to cause oxidative inactivation of JNK phosphatases 54 , JNK hyperactivation is a result of the dual action of GPx1 in regulating H 2 O 2 , which leads to activated ASK1 and inactivated JNK phosphatase

These two functions determine that the linker must undertake two tasks: first, it must ensure that ADC has good stability in the blood