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CD38 binding and enzymatic inhibition Mechanistic differences between isatuximab and daratumumab likely stem from their binding to different, non-overlapping epitopes on the L-shaped CD38 molecule [3, 4, 19]

Patients are typically pre-medicated with folic acid, vitamin B12, and a corticosteroid (like dexamethasone) to help reduce the incidence and severity of some of these side effects, particularly skin reactions and bone marrow suppression

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