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In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)

ROA, route of administration

By incorporating these natural sources regularly and paying attention to preparation methods that preserve their beneficial compounds, you can effectively support your body's antioxidant capacity

This dual behavior, referred to as the Estrogenic Paradox of resveratrol, reinforces its classification as a selective ER modulator [14]