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Description

PMID 30452312

Angiotensin II receptor blockers (ARB) selectively block the angiotensin II receptor (AT1 type), thereby inhibiting the effects of Ang II, such as vasoconstriction, increased blood pressure, aldosterone secretion, sodium and water retention, and sympathetic nervous system activation, producing pharmacological effects similar to those of ACEI

10.1111/febs.15715

The decreased expression of retinol dehydrogenase 10 has been proved to be the primary cause of these metabolic disturbances, leading to diabetic cardiomyopathy induced by lipid toxicity and ferroptosis