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By increasing the level of chaperone 70 protein, the studied drugs support the vital activity of the HIF-1 subunit and activate the synthesis of the HIF protein, which increases the expression of adaptation factors, such as: erythropoietin, vascular endothelial growth factor, glycolysis enzymes (lactate dehydrogenase, pyruvate dehydrogenase, phosphofructokinase, aldolase, etc.), and also ensures the operation of alternative energy systems in conditions of hypoxia (malate-aspartate shuttle mechanism)

Szumny D, Sozaski T, Kucharska AZ, Dziewiszek W, Pirecki N, Magdalan J, Chlebda-Sieragowska E, Kupczynski R, Szelg A, Szumny A (2015) Application of cornelian cherry iridoid-polyphenolic fraction and loganic acid to reduce intraocular pressure

This ingredient may not be safe for fungal acne as it contains fatty acids that can feed Malassezia

Nookongbut P, Kantachote D, Megharaj M, Naidu R (2018) Reduction in arsenic toxicity and uptake in rice ( Oryza sativa L.) by Asresistant purple nonsulfur bacteria