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ChaC1 expression varies in normal and cystic fibrosis bronchial epithelial cells, with low ChaC1 expression hypothesized to play a significant role in regulating the chronic inflammatory response induced by Pseudomonas aeruginosa (Pa) (132)

The development of DKD is closely linked to disturbances in glucose metabolism, which can lead to abnormal activation of mTORC1 and inhibition of autophagy, thereby exacerbating kidney damage (Zhao et al., 2024a)

Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock

Therefore, further studies aiming to understand the underlying molecular mechanisms regulating autophagy are required for the development of novel therapeutics